Bronchopulmonary cancer (CBP)

Definition:
Malignant lung tumors that start in glandular bronchial epithelium with screening asymptomatic often late because of developments in therapeutic effectiveness.
Holds:
Third place in women after breast and uterus
Place the male

Causes:
1. Smoking
2. Air pollution (industrial smoke, aromatic hydrocarbons)
3. Industrial professional factors (asbestos, dyes industry, processing of iron)
4. Preexisting lung injury:
– Bronchiectasis
– Injury post TBC
– Pulmonary Fibrosis
May. Genetic
Pathogenesis:

Classification after departure point:
1. CBP central onset (on a large Bronchitis – main or lobar)
– Initially appears as a thickening of the mucosa
– Then shows the development:
a) endobronchial – mass of irregular, brittle, prone to favoring luminal obstruction: atelectasis, infection or territory corresponding bronchi abcedarea
b) Exobronsic – to surrounding tissue or that it invades surrounding lymph pre sis (regional), hilar or mediastinal, late shows metastases in other organs at distant
2. CBP onset peripheral
– Without affecting large bronchi
– The extension to the pleura
– Late extending to regional lymph

Histopathological classification:
1. Squamous cell (epidermoid)
– Has a tendency to peel (possible diagnosis by cytological examination of bronchial secretion)
– Association with paraneoplastic syndromes
– Low tendency to disseminate
– Evolution to the cancer long (3-4 years)
2. The small cells
– Rapid progression by increasing tumor size
– Increased tendency to metastatic dissemination
– Increased tendency to relapse
3. Adenocarcinoma
– Introduce glandular structure
– Produce mucin
– Does rapid dissemination marrow metastases water way
4. Undifferentiated carcinoma with large cells
– Rapid progression to metastasis

Clinical picture:
Clinical manifestations vary depending on the pathological form, stage, histological type.
Respiratory symptoms:
– Cough, cough strength (mandatory investigated any man> 40 years with cough> 3 weeks)
– Hemoptysis in small quantities, repeated in Stade advanced layout “currant jelly”
– Shortness of breath – in late stages
Extrapulmonary manifestations:
– Fatigue unjustified
– Anorexia
– Marked decrease in weight
– Feverish
– Chest pain due to pleural damage
– Voice Biton by recurrent nerve damage
Physical exam:
– Pneumonic syndrome type condensation with the evolution of 3-4 weeks
– Axillary lymph nodes, supraclavicular
– Paraneoplastic manifestations, unusual behavior, arise through ectopic secretion of hormones from tumor:
1. By hypersecretion of ACTH Cushing syndrome associated with hyperpigmentation, metabolic alkalosis, hypokalemia
2. Hypersecretion of ADH – cause hyponatremia, headache, listlessness, vomiting
3. Hypersecretion of parathyroid hormone-like – hypercalcemia
4. Pierre-Marie pneumonic hypertrophic osteoarthropathy

5. Neuromyopathy syndromes: polymyositis, myasthenia, peripheral neuropathies

6. Migratory thrombophlebitis – Trousseau syndrome
7. Acanthosis nigricantis – by hypersecretion of melanin hyperpigmentation spots
8. Hippocratic fingers
9. Hemolytic anemia, leukemia syndromes
10. Gynecomastia (by releasing hormones estrogen – like)
– Events metastatic:
1. Dysphagia – compression on the esophagus
2. Hoarseness, voice Biton – superior laryngeal nerve compression and recurrent nerve
3. Dyspnea – phrenic nerve compression
4. Plegie brachial – shoulder, arm, shoulder blade – Pancoast-Tobias syndrome
5. In locating the apical – Claude syndrome – Bernard-Horner (miosis, enophthalmos, ptosis)
6. Cyanosis, edema in “Cloak” – compression VCS
7. Arrhythmias, cardiac tamponade – compressing the pericardium
8. Nodular hepatomegaly, liver mts
9. Pathological fractures – bone mts
10. Seizures, signs of intracranial hypertension – mts brain
11. Cutaneous nodule – mts Skin

Laboratory picture:
1. Chest radiograph
– Opaque hilarious, segmentation, lobar and bronchial lymph nodes
– Retraction mediastinum, pleura, diaphragm
– Erosion ribs, vertebral
– Pleurisy
– Pericarditis paraneoplastic
2. CT – extension and invasion of primary tumor
3. Bronhografie bronchoscopy and biopsy examination – diagnosis of certainty for endobronchial tumor development
4. Radiography bone scintigraphy – highlights bone metastases
5. MRI – highlights small mts
6. Abdominal CT, brain – highlights metastases
7. Abdominal-pelvic ultrasound – highlights liver metastases, lymph node distance (periaortice), ascites paraneoplastic
8. Sputum cytology – reveals malignant cells
9. Ex blood – ESR increased anemic and leukemic paraneoplastic syndrome, FA increased, increased gammaGT – liver metastases

TNM staging – tumor / node / metastasis

T – primary tumor
Tx – can not Evidential
Tis (in situ) – stage tumor cells – anatomical and pathological diagnosis
T0 – no highlight
T1 – diameter ❤ cm
T2 – diameter> 3cm
T3 – extension to the thoracic wall, pleura, diaphragm, pericardium
T4 – invasion of the mediastinum

N – nodal involvement
N0 – no lymph node involvement
N1 – catch peribronchial or hilar lymph
N2 – catch of the hull and mediastinal lymph
N3 – catch scalene and supraclavicular lymph

M – distant metastases
M0 – no metastases
M1 – metastasis

Occult stage – TxN0M0
Stage 0 (in situ) – TisN0M0
Stage 1 – T1-2N0M0
Stage 2 – T1-2N1M0
Stage 3 – T3N0-1M0 or T1-3N2M0
Stage 4 – Any T, Any N, M1
Treatment:
1. Surgical
Criteria:
– By histology
– After stage (stages 1 and 2)
– By overall (lung function, heart, age, pre-existing conditions,)
– By location
– After remaining functional parenchyma
Types of interventions:
– Lobectomy
– Bilobectomie
– Segmentectomie
– Pneumonectomy
2. Radiotherapy:
– In advanced stages without mts distance
– The curative – when surgery is contraindicated
– The palliative effect – lowering turmoil hilarious or mediastinal invasion in order to improve quality of life
– Preoperative – decreases tumor volume decreases invasion of neighboring
– Surgery – in the treatment of incompletely resected tumors

Side Effects:
– Esophagitis radical
– Loss of appetite, vomiting, nausea
– Dry cough
– Pneumonia radical
– Gastritis radical
3. Chemotherapy:
Directions:
– CBP with contraindications to surgery or radiotherapy
– CBP expanded with mts
– After surgery
– Along with radiotherapy in locally advanced forms, unresectable

It utilizes CANINE – act on the tumor cell metabolism decreases tumor cell proliferation
1. CISPLATIN
2. Vinblastine
3. Mitomycin C
4. Etoposide
The scheme utilizes each patient tailored combinations of chemotherapy.

Side Effects:
1. loss of appetite, nausea, vomiting 5. neurotoxicity
2. Anam, granulocytopenia, thrombocytopenia 6. ARF
3. immunosuppression 7. alopecia
4. cardiac fibrosis

 

Advertisements

, , , , , , , , , ,

  1. #1 by radiografias on May 7, 2013 - 3:18 pm

    Hmm is anyone else having problems with the images on this blog loading? I’m trying to determine if its a problem on my end or if it’s the blog. Any feed-back would be greatly appreciated.|

    Like

    • #2 by Simonica on May 8, 2013 - 1:30 am

      I do not believe that to be a problem at the site is likely to you if someone else more have problems please contact me

      Like

  2. #3 by Louis Vuitton Handbags Outlet on May 12, 2013 - 1:33 am

    Hi! Quick question that’s totally off topic. Do you know how to make your site mobile friendly? My website looks weird when viewing from my iphone. I’m trying to
    find a theme or plugin that might be able to fix this issue.
    If you have any suggestions, please share. Thanks!

    Like

  3. #4 by NFL Jerseys Wholesale on May 16, 2013 - 5:17 pm

    I don’t know whether it’s just me or if perhaps everybody else encountering issues with your blog.
    It looks like some of the written text on your content are running off the screen.
    Can someone else please comment and let me know if this
    is happening to them as well? This could be a issue with my internet browser because
    I’ve had this happen before. Appreciate it

    Like

  4. #5 by Michael Kors on May 20, 2013 - 10:42 am

    Just want to say your article is as astounding.
    The clearness in your post is just spectacular and i could assume you’re an expert on this subject. Well with your permission allow me to grab your RSS feed to keep up to date with forthcoming post. Thanks a million and please keep up the rewarding work.

    Like

  5. #6 by Clayton on May 21, 2013 - 8:35 am

    excellent publish, very informative. I’m wondering why the opposite specialists of this sector don’t
    realize this. You should proceed your writing.
    I’m sure, you’ve a great readers’ base already!

    Like

  6. #7 by NFL Cheap Jerseys on May 21, 2013 - 9:55 am

    Post writing is also a excitement, if you
    be familiar with afterward you can write otherwise it is difficult to write.

    Like

  7. #8 by Gafas De Sol Oakley on May 21, 2013 - 3:33 pm

    Please let me know if you’re looking for a writer for your blog. You have some really great articles and I think I would be a good asset. If you ever want to take some of the load off, I’d love to write some articles for your blog in exchange for a link back to
    mine. Please shoot me an e-mail if interested.
    Many thanks!

    Like

  8. #9 by http://www.explorethecapabilities.com/ on May 23, 2013 - 8:05 pm

    This is really interesting, You are a very skilled blogger.
    I have joined your feed and look forward to seeking more of your magnificent post.
    Also, I’ve shared your site in my social networks!

    Like

  9. #10 by Louis Vuitton Bags on May 24, 2013 - 4:32 pm

    What’s up, just wanted to mention, I liked this post. It was funny. Keep on posting!

    Like

  10. #11 by Michael Kors Handbags on May 24, 2013 - 10:16 pm

    I’m excited to find this website. I want to to thank you for ones time for this wonderful read!! I definitely really liked every little bit of it and i also have you saved to fav to see new stuff on your blog.

    Like

  11. #12 by Francine on May 25, 2013 - 1:19 pm

    you are truly a excellent webmaster. The web site loading velocity is incredible.
    It kind of feels that you’re doing any distinctive trick. Also, The contents are masterwork. you have done a magnificent task in this topic!

    Like

  12. #13 by Authentic Sidney Crosby Jersey on May 26, 2013 - 8:32 am

    I enjoy reading through an article that can make people think.
    Also, thanks for allowing me to comment!

    Like

  13. #14 by Air Jordan Pas Cher on May 27, 2013 - 5:23 pm

    My programmer is trying to convince me to move
    to .net from PHP. I have always disliked the idea because of the expenses.
    But he’s tryiong none the less. I’ve been using Movable-type on a number of websites for about a year and am
    worried about switching to another platform. I have heard fantastic things
    about blogengine.net. Is there a way I can transfer all my wordpress posts into it?
    Any kind of help would be greatly appreciated!

    Like

  14. #15 by Evgeni Malkin Jersey on May 28, 2013 - 11:06 pm

    Hey there! Do you know if they make any plugins to assist with Search Engine Optimization?
    I’m trying to get my blog to rank for some targeted keywords but I’m not seeing
    very good gains. If you know of any please share. Kudos!

    Like

  15. #16 by cheap jerseys on May 29, 2013 - 12:05 am

    Hello there! Would you mind if I share your blog with
    my myspace group? There’s a lot of folks that I think would really enjoy your content. Please let me know. Thank you

    Like

  16. #17 by Air Jordan 2013 on May 29, 2013 - 2:57 am

    My spouse and I absolutely love your blog and find most of your post’s to be just what I’m looking for.

    Does one offer guest writers to write content to
    suit your needs? I wouldn’t mind producing a post or elaborating on some of the subjects you write concerning here. Again, awesome blog!

    Like

  17. #18 by micro jobs on May 29, 2013 - 2:58 am

    Aldo, I’m not sure what part of the message you’re requesting, however as long as the content remains in tack w/credit to me, you may use and inform me of where you posted the message. Kimyon micro jobs http://www.sleekservice.com

    Like

  18. #19 by Louis Vuitton Pas Cher on May 29, 2013 - 4:32 am

    We’re a group of volunteers and opening a new scheme in our community. Your site provided us with valuable info to work on. You have done a formidable job and our entire community will be thankful to you.

    Like

  19. #20 by Air Jordan Femme on May 29, 2013 - 8:36 am

    Really no matter if someone doesn’t know after that its up to other viewers that they will assist, so here it occurs.

    Like

  20. #21 by Abercrombie on May 30, 2013 - 1:39 am

    It’s actually a cool and useful piece of info. I’m satisfied that you shared this
    helpful info with us. Please stay us informed like this.

    Thanks for sharing.

    Like

  21. #22 by Louis Vuitton Bags on May 30, 2013 - 5:00 pm

    It’s perfect time to make a few plans for the longer term and it is time to be happy. I have learn this publish and if I may I want to recommend you few interesting issues or tips. Perhaps you can write subsequent articles regarding this article. I want to learn more things about it!

    Like

  22. #23 by Chaussure De Foot Pas Cher on May 31, 2013 - 4:51 pm

    Magnificent goods from you, man. I have understand your
    stuff previous to and you’re just extremely excellent. I really like what you’ve acquired
    here, certainly like what you’re saying and the way in which you say it. You make it entertaining and you still care for to keep it smart. I can’t wait to read
    far more from you. This is actually a terrific website.

    Like

  23. #24 by Cheap Jerseys on June 2, 2013 - 12:40 am

    Hi there! I could have sworn I’ve been to this website before but after browsing through some of the post I realized it’s new to me.

    Anyways, I’m definitely delighted I found it and I’ll
    be book-marking and checking back frequently!

    Like

  24. #25 by link on June 2, 2013 - 12:02 pm

    I don’t comment, but after reading a bunch of responses on this page Bronchopulmonary cancer (CBP) | General Medicine for Beginners. I do have a few questions for you if it’s allright.
    Could it be only me or do some of these comments appear
    like they are left by brain dead folks? 😛 And, if you
    are posting at other places, I would like to follow everything new you
    have to post. Would you post a list of every one of
    your public sites like your linkedin profile, Facebook page
    or twitter feed?

    Like

  25. #26 by Wholesale Jerseys on June 2, 2013 - 3:57 pm

    bookmarked!!, I love your site!

    Like

  26. #27 by PR2 Web 2.0 Creation For $5 on June 3, 2013 - 12:20 am

    If you want to become an authority in your niche, then you need this seo gig. => http://goo.gl/ORSyh

    Like

  27. #28 by Mulberry UK on June 3, 2013 - 1:15 am

    This web site truly has all of the information and facts I
    needed about this subject and didn’t know who to ask.

    Like

  28. #29 by Air Max on June 3, 2013 - 1:43 am

    If you are going for most excellent contents like me, just go to see this web page everyday for the reason that it presents
    feature contents, thanks

    Like

  29. #30 by rebafh55 on June 4, 2013 - 12:49 am

    Porn Every heyday :
    http://booty.net.erolove.in/?maggie
    free full-length mp4 porn naked hot sexy girls woman porn re hot and free virgin pussy sex teens etc free videos and pi free dog fuck movies cartoon strips about carpentry hot russian girls nude peirced video gardening mama online

    Like

  30. #31 by gretawu1 on June 4, 2013 - 2:37 am

    hd video porn full hottest adult stars of all time building a natural stone waterfall black babies names site erotic friends anal fisting lesbian pregnant japanese nipples muscle relaxant drugs bmevideo cum
    http://anal.erolove.in/?alma
    star trek voyager 7×25 endgame part bisevub nhac fim boys over flower anal muncher tube bodybuilding christopher wright nude sixteen age sex turk amator porn movies how to massage a girl best free lezbian porn video
    http://bdsmgalls.net/?sexy-andre
    xxx punjabi tube watch indian free desi sexy movies bbw gratuit

    Like

  31. #32 by Read This on June 5, 2013 - 8:38 am

    I don’t even understand how I finished up right here, however I believed this put up was good. I do not know who you might be however definitely you are going to a well-known blogger if you aren’t already.

    Cheers!

    Like

  32. #33 by New Kevin Durant Shoes on June 24, 2013 - 1:12 pm

    Hello, everything is going perfectly here and ofcourse every one is sharing data, that’s truly fine, keep up writing.

    Like

    • #34 by Simonica on June 24, 2013 - 4:12 pm

      Ok

      Like

  33. #35 by Jeremy Scott on July 3, 2013 - 2:38 am

    If you wish for to improve your knowledge just keep visiting
    this website and be updated with the most recent information posted
    here.

    Like

  34. #36 by Michael Kors Bags on July 24, 2013 - 7:51 pm

    Having faced the Oakland Raiders Take Chris Ivory from
    Michael Kors Bags? With a Party Pass, fans get the chance to
    make the costume yourself. I have offered and the NFL draft a way to do
    that on their defensive line.

    Like

  35. #37 by Juliet on August 3, 2013 - 10:33 am

    ‘Trademark Michael Kors Outlet had been seeking more than $1million damages in a Manhattan federal court for alleged trademark infringement. 00 to 500 00 per pair and there are some rules that they follow.

    Like

    • #38 by Simonica on January 25, 2014 - 9:19 am

      I do not understand what you mean

      Like

  1. 手機殼

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: