DZ = cr metabolic disease. – Major disorder is hyperglycemia which is based on scarcity absolute / relative insulin
Type I insulin-dependent diabetes
ØDebut => 40 years
Type II diabetes Noninsulinodependent
ØDebut 40 years =>
Pharmacodynamic actions:
The biological effects of

a carbohydrate metabolism:
↓ glucose: – ↓ glycogenolysis
– ↑ glycogenesis
– TRANSPORT transmembrane G ↑
B. Lipid metabolism: – ↓ lipolysis
– ↑ CONSUMPTION DC (muscles)
c protein metabolism:
– ↑ LIVER PROTEIN anabolism and muscle
– ↓ protein catabolism (↓ urea)

a.HIPOGLICEMIA (commonly encountered): sweating, pallor, hunger, anxiety, tremor
b.ALERGIA insulin – rare;
c.LIPODISTROFIA after insulin administration in the same place long

Types of insulin
A. I. animals: pigs and cattle
I. b component (MC): I animals chromatographic purification
v. I. human (HM) genetically engineered with superior tolerance, without impurities
II. After installing and hypoglycemic TIME

I. A fast-acting, short
! SC.; debut 30 ‘, duration 6-8 hours;
intermediate-acting b I.
! s.c., beginning 1-2 hours Duration 12 – 4:00 p.m.
Humulin N, Insulatard, Insuman BASAL
nInsuline with long-acting – Long-acting analogues Lantus Levemir
start – 2:00, action-24 hours
nInsuline premixed
– Blends 20/80, 30/70, 40/60, the short-acting insulin and NPH – Humulin M3 Mixtard 30HM, Insuman Comb 25, Insuman Comb 50 – debut 30 minute action-4:00 p.m.
– Mixtures of rapid-acting analogues and NPH Humalog Mix 25, Humalog Mix 50, NOVOMIX 30; debut – 25 minutes act.-10:00
nintroducerea air in the bottle
(How many units to be taken)
nfixarea insulin dose by
Its aspiration is not slow to
I do not antiseptizeaza injection
nscoaterea needle without compressing
region then
nSeringa insulin-100U/ml,
Needle 12, 8, 6 mm which can be
reused to produce discomfort
puncture or for 7 days
Management Rules
nCunoaşterea injection site – subcutaneous injection (arm, thigh, abdomen, buttock);
nAlternarea injection site to prevent lipodystrophy;
nAlternarea region of administration in order to prevent changes in the absorption and overall risk of late;
n Avoiding insulin administration regions to be requested immediately by intense exercise (increased absorption of insulin, I risk of hypoglycaemia);
Management Rules
nCondiţii Storage
– Avoid extreme temperatures and direct exposure to sunlight
– Keep at room temperature – 14 to 30 days
– Open bottle stored at 2-8 ° C within 1-2 months
– Dark bottle stored at 2-8 ° C until expiry
Knowing ways to manage their
a) s.c. deep in region: – deltoid
– Thighs
– Abdominal wall
– Portable with pen
– Subcutaneous catheter (modern pumps
b) i.v. ketoacidosis coma
nCunoaşterea insulin doses
nCunoaşterea side effects of insulin therapy:
– Hypoglycaemia – insulin injection sites to be requested immediately by exercise;
-Deviations from the diet
– Lipodystrophy
-Practical allergy to insulin. eliminated by using human insulin
– Edema, blurred vision, weight gain
– Pain by injection of needle used, scrap alcohol on the skin, intradermal injection,
– Use of insulin in the refrigerator cold
nOnce injection:
1.Prevenirea any hypoglycemia (sugar candy);
February. In case of doubt regarding hypo-or hyperglycemia is preferable to treat the case as hypoglycemia;
Three. If hypoglycemic patients who can not swallow should be administered sc glucagon, insulin syringe;
Always wear 4.Pacientul carry a medical documents identifying him as a diabetic and mention the type and dosage of insulin needed.
Timing of insulin
Human nInsulinele: is administered 30-45 min before meal
nAnalogii insulin: is given immediately before the meal
nFor human insulin required 3 meals / day and 3 snacks
nFor insulin analogues are not usually necessary snacks.
I. Classical treatment

a) 3 doses / 24 H
– Morning (D1) – the largest
– Lunch (D2) – less than D1
– Evening – comparable to D1
b) 2 doze/24 h
– Am – 2/3 D/24
– Evening third of D/24
II. Intensified treatment
• Assessment of needs I by blood glucose and / or glycosuria
• Very effective!
• Disadvantages: – ↑ frequency of hypoglycaemia
– Weight tend ↑
– Cost ↑


, , , , , , ,

  1. #1 by chucherias on July 5, 2013 - 5:05 pm

    My brother suggested I may like this web site. He was entirely right.

    This submit truly made my day. You cann’t imagine just how a lot time I had spent for this info! Thanks!


  2. #2 by alexander mcqueen clutch on July 6, 2013 - 6:15 pm

    one of our guests a short while ago suggested the following website


  3. #3 by winstrol diet and workout on July 8, 2013 - 12:14 am

    genotropin hgh


  4. #4 by Buy Social Bookmarking Services on July 11, 2013 - 8:46 am

    Nice post. I learn something new and challenging on sites
    I stumbleupon everyday. It will always be helpful to read through content from other authors and use a
    little something from other websites.


  5. #5 by how to lose 10 pounds on July 11, 2013 - 3:15 pm

    After I initially left a comment I appear to have clicked the -Notify me when
    new comments are added- checkbox and now every
    time a comment is added I receive four emails with the same comment.
    Is there a means you can remove me from that service?
    Thanks a lot!


  6. #6 by hauppauge hd pvr on July 13, 2013 - 10:52 pm

    Have you ever thought about including a little bit more than just your articles?
    I mean, what you say is fundamental and everything. But just imagine if
    you added some great visuals or video clips to give your posts more, “pop”!

    Your content is excellent but with pics and videos, this website could certainly be one of the best in its field.
    Fantastic blog!


  7. #7 by Jerold Schaumburg on July 15, 2013 - 2:15 pm

    Observed your post really remarkable in truth. I actually loved browsing it therefore you make pretty some excellent factors. I will bookmark this web site for the future! Relly terrific short article.


  8. #8 by chris farrell membership review on July 15, 2013 - 6:28 pm

    The such as you read my head! You appear to recognize much roughly this kind of, as if you wrote the hem ebook inside it or anything. I feel that you may employ a few percent to tension the material household a bit, on the other hand as an alternative to of which, this is wonderful site. A great go through. I most certainly will absolutely come back.


  9. #9 by sexdate on July 15, 2013 - 11:22 pm

    Thanks for publicing this awesome information. Keep up this good work. I’ll subscribe to your weblog also. thanks!


  10. #10 by www on July 16, 2013 - 4:11 am

    magnificent points altogether, you simply received
    a new reader. What would you suggest in regards to your submit that you just made
    some days ago? Any certain?


  11. #11 by Latest technology news on August 2, 2013 - 10:36 am

    Hello! Someone in my Myspace group shared this website with us so I came to take a look. I’m definitely loving the information. I’m book-marking and will be tweeting this to my followers! Outstanding blog and outstanding design.


  1. diesel
  2. click
  3. driving schools milton keynes

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: